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The Strategic Program for Analyzing Complexity and Evaluating Systems (SPACES MERL) project is an activity funded by USAID’s Global Development Lab and the Bureau for Policy, Planning and Learning (PPL). This three-year activity aims to bring a variety of tools and methodologies that decision-makers can use (alone or in combination) to provide comprehensive systems analysis. The activity is being implemented from 2015 to 2018 by a consortium of organizations expert in systems and complexity, including the Global Obesity Prevention Center (GOPC) at Johns Hopkins University (Prime), Global Knowledge Initiative (GKI), LINC and ResilientAfrica Network (RAN). This Systems and Complexity White Paper is a collaborative effort of the SPACES MERL team, designed to frame the international development landscape, with particular reference to USAID-funded activities, for application of systems and complexity approaches to design, monitoring and evaluation. Customized to the systems and complexity layperson with in-depth knowledge of international development practice, the objectives of this white paper are three-fold:  Provide an overview of systems and complexity practice, its current state of application and relevance to international development practice;  Establish a taxonomy of systems and complexity tools, highlighting the fit of those offered by SPACES MERL within the wider landscape; and  Review and provide information on application of SPACES MERL tools, their purpose and construction, required data, and their applicability to specific contexts.