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The Architecture of Learning: Systems, Infrastructure, and Leadership for Health System Transformation Session Description Health care can improve as a system only if its parts are aligned around the shared purpose of better health for all. This talk will explore how learning health systems integrate science, data, and culture to enable continuous improvement and innovation. Through real-world examples from a single patient’s question to national learning networks, we will examine how infrastructure, leadership, and community engagement create the conditions for systems that learn and improve at scale.