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This commentary focuses on the difference between a theory of change and change theory, as it relates to systemic change projects in STEM higher education. A theory of change is project-specific and related to evaluation. It makes the underlying rationale of a project explicit, which supports planning, implementation, and assessment of the project. In addition, a theory of change is often required by funding agencies as part of grant proposals. In contrast, change theories represent theoretical and empirically grounded knowledge about how change occurs that goes beyond any one project. Ideally, a theory of change is informed by change theories. This essay describes the connections between a theory of change and change theory and provides examples of how change theory can inform a project’s theory of change. Grounding projects in change theory allows change agents to draw on existing knowledge and to better contribute to our collective knowledge about how to achieve meaningful change in STEM higher education.