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This Rapid Evidence Assessment (REA) examines current evidence on the effectiveness of interventions to combat human trafficking in four South Asian countries (Bangladesh, India, Nepal, and Pakistan). This REA is being carried out as part of a wider assignment for the UK Department for International Development (DFID), with the overall objective of synthesising evidence on the effectiveness of interventions that tackle modern slavery in South Asia. Two REAs were conducted on different types of modern slavery, one on human trafficking for labour and sexual exploitation, and another on child labour (Idris et al., 2020). The research question for this REA is: ‘What has been the effect of interventions to combat and/or reduce sexual and labour exploitation in Bangladesh, Pakistan, India, and Nepal?’ Trafficking in persons is a form of ‘modern slavery’, which is an umbrella term for the variety of situations in which someone is forcibly controlled by an individual or group for the purpose of exploitation. The Global Slavery Index estimated that, on any given day in 2016, 40.3 million people were victims of modern slavery, including 24.9 million people in forced labour and 15.4 million people in forced marriage. Of the estimated almost 25 million people in modern slavery in Asia, 66% were exploited for labour (Global Slavery Index, 2018).