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USAID’s Program Cycle Operational Policy (ADS 201) provides guidance to missions and other operating units on how to implement the Program Cycle. A key principle of the Program Cycle is to “Promote Sustainability through Local Ownership.” The purpose of this Technical Note is to describe the “5Rs Framework”, a practical methodology for supporting sustainability and local ownership in projects and activities through ongoing attention to local actors and local systems. This Note is rooted in USAID’s 2014 Local Systems Framework paper, which establishes that achieving sustained improvement in development results depends on the contributions of multiple and interconnected local actors. That document also states that USAID needs to improve its systems practice if it is to engage local actors and strengthen local systems more effectively and thus realize sustained results more consistently. The 5Rs Framework, also introduced in the Local Systems Framework, is intended as a simple and practical tool to promote good systems practice. The 5Rs Framework highlights five key dimensions of systems: Results, Roles, Relationships, Rules and Resources. Collectively these 5Rs can serve as a lens for assessing local systems and a guide for identifying and monitoring interventions designed to strengthen them. This Technical Note is divided in two parts. The first part provides an introduction to the 5Rs Framework and the systems practice from which it emerges. The second part demonstrates how systems practice can be embedded in the Program Cycle by continuously applying the 5Rs, especially to the design, implementation, and monitoring of USAID projects and their accompanying activities.